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目的研究不同手术方法对小儿喉乳头状瘤的治疗效果。方法对吉林大学一院1998年至2007年收治的确诊小儿喉乳头状瘤19例随访病历资料进行分析。根据手术方式分为支撑喉镜下单纯钳除组(A组)及支撑喉镜下激光切除组(B组)。记录不同方法治疗后患儿肿瘤复发情况,复发后作为新病例再次进入下次随访,观察其复发期限,以生存分析法(包括生存曲线绘制法)应用于复发事件和复发时间的分析及复发曲线的绘制,并以此作为不同手术方式治疗的疗效指标。结果本组患儿为19例,每例均行≥1次的手术,每次手术数据当作1个分析对象,19例患儿共行手术52例次,A组手术为21例次,B组手术为31例次。2组复发曲线之间无交叉,具有可比性。不同组别复发曲线位置不同,支撑喉镜下激光切除治疗小儿喉乳头状瘤,在延长复发时间上明显优于单纯钳夹去除肿物的治疗方法(P<0.01)。结论儿童喉乳头状瘤激光手术创伤小,较传统治疗法能够有效延长复发时间,效果较好。
Objective To study the effect of different surgical methods on pediatric laryngeal papilloma. Methods The data of 19 cases of pediatric laryngeal papilloma diagnosed in our hospital from 1998 to 2007 were analyzed. According to the operation mode, the patients were divided into simple clamp group (group A) and laryngoscope group (group B). The recurrence of the tumor in children with different methods was recorded. After recurrence, the patients were re-entered the next follow-up, and the recurrence period was observed. Survival analysis (including survival curve mapping method) was applied to the analysis of recurrence and recurrence time and recurrence curve Of the draw, and as a result of different surgical methods of treatment efficacy indicators. Results The group of 19 children were enrolled in this study. Each case underwent ≥1 surgery. The data of each operation were regarded as one analysis object. Twenty-nine children underwent operation in 52 cases. The patients in group A received operation in 21 cases. Group operation was 31 cases. No recurrence curve between the two groups, comparable. The recurrence curves of different groups were different. The laryngectomy under laryngoscope treatment of laryngeal papilloma of the larynx was significantly better than the simple clamp removal of the tumor (P <0.01). Conclusions The laryngeal papilloma of the larynx in children is less traumatic than traditional therapies, which can effectively prolong the relapse time.