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目的:研究观察中药舒肝胶囊对长期“怒”心理应激雌性大鼠的行为学和体重、子宫及卵巢指数的改变。方法:将24只雌性SD大鼠随机分为3组(正常对照组、“怒”模型组、舒肝胶囊组),每组8只。模型组予夹尾间接激怒法造模4周,舒肝胶囊组在造模的同时予舒肝胶囊0.54 g·kg-1灌胃,给药4周。另外群居饲养10只大鼠作为入侵者激怒。记录并分析各实验组大鼠的行为学改变,体重及子宫、卵巢的指数,评价模型质量及中药干预的效果。结果:模型组较正常组水平、垂直及总得分均显著增高(P<0.01),中央格时间、粪便粒数增多,修饰次数、修饰时间显著减少(P<0.01);体重减轻(P<0.05);卵巢指数显著降低(P<0.01);舒肝胶囊组较模型组水平、垂直及总得分均显著降低,差异有显著性(P<0.01);中央格时间延长、粪便粒数减低,修饰次数及修饰时间增多(P<0.05或P<0.01);卵巢指数显著增高(P<0.01)。结论:舒肝胶囊对改善“怒”引起的敏感、紧张情绪有一定的改善作用,对缓解“怒”引起的体重、子宫及卵巢指数的改变有一定效果。
Objective: To observe the changes of behavior and body weight, uterus and ovary index of Chinese medicine Shugan Capsule on long-term “Anger” psychological stress female rats. Methods: Twenty-four female Sprague-Dawley rats were randomly divided into three groups (normal control group, model group “Shui”, Shugan capsule group) with 8 rats in each group. The rats in the model group were induced by indirect irritation for 4 weeks. Shu-shu capsule group was given Gushang capsule 0.54 g · kg-1 orally for 4 weeks. In addition, 10 rats were housed in groups as an intruder. The behavioral changes, body weight, uterus and ovary index of each experimental group were recorded and analyzed, and the quality of model and the effect of Chinese medicine intervention were evaluated. Results: Compared with the normal control group, the level, vertical and total score of the model group were significantly increased (P <0.01), the central grid time, the number of stool particles increased, the number of modification and modification time significantly decreased (P <0.01) ); Ovarian index was significantly lower (P <0.01); Shugan Capsule group than the model group horizontal, vertical and total score were significantly lower, the difference was significant (P <0.01); the central grid time, fecal particle number, modification (P <0.05 or P <0.01). The ovarian index increased significantly (P <0.01). Conclusion: Shugan Capsule can improve the sensitive and nervous emotions caused by improving the irritation of the anger, and has a certain effect on alleviating the change of body weight, uterus and ovary index caused by.