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目的分析及评价新辅助化疗联合手术治疗对Ⅱb期宫颈癌的疗效。方法将所研究的52例Ⅱb期宫颈癌患者划分为观察组和对照组,对观察组(n=36)患者行新辅助化疗联合手术治疗,对照组(n=16)患者只行手术治疗,对比两组患者疗效,包括病理检查、术中出血量、盆腔淋巴结转移情况等。结果观察组患者PR 19例,CR 3例,有效率达61.1%。与对照组相比在盆腔淋巴结转移率、术中出血量、癌周间质细胞反应等方面,差异有统计学意义(P<0.05)。结论新辅助化疗联合手术不仅能够降低盆腔淋巴结转移率,而且有助于缩小肿瘤体积,是治疗Ⅱb期宫颈癌的有效方法 。
Objective To analyze and evaluate the efficacy of neoadjuvant chemotherapy combined with surgical treatment of stage Ⅱ b cervical cancer. Methods Fifty-two patients with stage Ⅱb cervical cancer were divided into observation group and control group. Neoadjuvant chemotherapy combined with surgery was performed in the observation group (n = 36). Patients in the control group (n = 16) The curative effect of two groups was compared, including pathological examination, intraoperative blood loss, pelvic lymph node metastasis and so on. Results The observation group of patients with PR in 19 cases, CR 3 cases, the effective rate was 61.1%. Compared with the control group in the pelvic lymph node metastasis rate, intraoperative blood loss, cancer week interstitial cell response, the difference was statistically significant (P <0.05). Conclusion Neoadjuvant chemotherapy combined with surgery can not only reduce the pelvic lymph node metastasis rate, but also help to reduce the tumor volume, is an effective method for the treatment of stage Ⅱ b cervical cancer.