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在过去五年中,对各种癌症的治疗给药方案有了很大的发展,主要进展在于应用如顺铂和鬼臼乙叉苷治疗儿童肿瘤、睾丸和卵巢的生殖细胞瘤和小细胞型肺癌。但令人担忧的是一些常见肿瘤如结肠和乳腺癌、非小细胞型肺癌对大多数药物治疗方案还是有顽固的耐药性。最近开发的新药确实几乎没有一个具有专一的抗癌作用,它们都具抗增殖作用。这是由于药物设计思想建立在对付共同的靶——脱氧核糖核酸(DNA)上,而至今尚未找到专一性的抗DNA药物。这些抗癌药的毒性甚为严重,因此设计的重点不得不转向其他的细胞内靶,如核糖核酸(RNA)、
In the past five years, the treatment regimens for various cancers have been greatly improved. The major advances have been made in the treatment of germ cell tumors, testicular and ovarian germ cell tumors and small cell types in children with cisplatin and etoposide Lung cancer. However, some common tumors such as colon and breast cancer are of concern. Non-small cell lung cancer still has stubborn resistance to most drug regimens. Recently developed new drugs do have almost no one with a specific anti-cancer effect, they are anti-proliferative effect. This is because the idea of drug design is based on the common target of DNA, and no specific anti-DNA drugs have so far been found. The toxicity of these anti-cancer drugs is so severe that the focus of the design has to turn to other intracellular targets such as RNA,