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绝大多数儿童类脂性肾病者的肾脏在光学显微镜下仅呈轻微损害,他们的肾病综合征通常经皮质激素治疗后都可缓解。预后一般是好的。成人的类脂性肾病情况也相似。但近几年来发现有一些小儿和成人类脂性肾病会发展为肾功能衰竭。这些病例的肾脏活检的特点是肾小球硬化。本文报道对成人类脂性肾病的观察。作者根据组织学上的改变,把病人分为轻微病变型和局灶性肾小球硬化型两类,以便了解这两类型对治疗的反应、临床过程及其预后。
The kidneys of most children with nephrotic nephropathy show only mild damage under light microscopy, and their nephrotic syndrome is usually relieved after corticosteroid treatment. The prognosis is generally good. The incidence of lipoidic nephropathy in adults is similar. However, in recent years, it has been found that some pediatric and adult lipithrombosis develop renal failure. Kidney biopsies of these cases are characterized by glomerulosclerosis. This article reports the observation of adult lipid-induced nephropathy. Based on histological changes, the authors classify the patients into two groups: minimal and focal forms of glomerulosclerosis in order to understand the response to these two types of treatment, their clinical course, and their prognosis.