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目的 :探讨药物性糖尿病的发生因素以及降糖药物的不良反应。方法 :调查了我院 6年来收治的糖尿病患者的病历 6 81份 ,重点分析了药物性糖尿病以及与使用降糖药物有关的已发生不良反应的病历共 5 2例。结果 :药物性糖尿病 13例占 6 81例的 1.91% ;由于用药不当导致原有糖尿病复发或加重者 36例占 6 81例的 5 .2 9% ;应用降糖药物造成原有肝病复发者 3例占 6 81例的 0 .0 4%。结论 :不恰当的用药是糖尿病发生、延误治疗和复发诸多因素中的一个危险因素 ;磺酰脲类口服降糖药物的肝毒性应引起足够的重视。
Objective: To investigate the occurrence of drug-induced diabetes and the adverse reactions of hypoglycemic agents. Methods: A total of 6 81 medical records of diabetic patients admitted to our hospital over the past 6 years were investigated. Drug-induced diabetes and 52 cases of adverse medical reactions related to the use of anti-diabetic drugs were analyzed. Results: 13 cases of drug-induced diabetes accounted for 1.91% of 6 81 cases; due to improper medication lead to recurrence or exacerbation of existing diabetes 36 cases accounted for 529% of 6 81 cases; the use of antidiabetic drugs caused by the original recurrence of liver disease 3 Cases accounted for 0.81% of 6 81 cases. Conclusion: Improper medication is one of the risk factors of diabetes mellitus, delayed treatment and relapse. The hepatotoxicity of sulfonylurea oral hypoglycemic drugs should be given enough attention.