论文部分内容阅读
目的:探讨血浆内脏脂肪素与非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)患者内脏脂肪厚度的关系.方法:选择进行健康体检的人员共170例;分成两组:即NAFLD组110例(分轻度40例、中度40例和重度30例),健康对照组60例,入选者空腹检查血压、身高、体质量、臀围、腰围、甘油三脂、总胆固醇、血糖、肝功能、血浆胰岛素水平和血浆内脏脂肪素测定,计算体质量指数(body mass index,BMI)、腰臀比(waist-hip ratio,WHR),并用稳态模型评估的胰岛素抵抗指数(homeostasis model assessment,HOMAIR),超声测量内脏脂肪厚度.结果:健康对照组与NAFLD组的内脏脂肪厚度、BMI、WHR、HOMA-IR、内脏脂肪素等指标差异存在统计学意义(P<0.05),多元线性回归分析显示,内脏脂肪素与内脏脂肪厚度呈正相关(P<0.05).其相关性随脂肪肝的加重而增强(r值依次为0.363,0.687,0.722,P<0.05).结论:NAFLD患者血浆内脏脂肪素水平及超声测定的内脏脂肪厚度明显高于健康人群;提示血浆内脏脂肪素水平与内脏脂肪厚度呈强烈相关性.
Objective: To investigate the relationship between plasma visfatin and visceral fat thickness in patients with nonalcoholic fatty liver disease (NAFLD) .Methods: A total of 170 patients selected for physical examination were divided into two groups: 110 patients in NAFLD group (40 cases in mild, 40 cases in moderate and 30 cases in severe) and 60 cases in healthy control group. Blood pressure, height, body mass, hip circumference, waist circumference, triglyceride, total cholesterol, blood sugar, liver function , Plasma insulin levels and plasma visfatin, and calculated body mass index (BMI) and waist-hip ratio (WHR). The homeostasis model assessment (HOMAIR) ), And visceral fat thickness were measured by ultrasound.Results There were significant differences in visceral fat thickness, BMI, WHR, HOMA-IR and visceral adiponectin between healthy control group and NAFLD group (P <0.05), and multivariate linear regression analysis , Visceral fat and visceral fat thickness was positively correlated (P <0.05), and the correlation was enhanced with the increase of fatty liver (r values were 0.363,0.687,0.722, P <0.05) .Conclusion: Plasma visfatin water The thickness of visceral fat measured by plain and ultrasonography was significantly higher than that of healthy people, suggesting that there was a strong correlation between plasma visfatin levels and visceral fat thickness.