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目的探讨维生素D联合二甲双胍、中药短期治疗对PCOS患者内分泌代谢紊乱的影响。方法选择生殖中心初次就诊PCOS患者270例,随机分为3组,每组均为90例,A组给予二甲双胍治疗,B组给予二甲双胍+中药治疗,C组给予二甲双胍+中药+维生素D治疗;治疗周期均为3个月。所有患者治疗前后测定FSH,LH,E2,T,SHBG,维生素D水平及OGTT,并计算BMI、FAI及HOMA-IR。结果治疗后A、B、C组相比BMI、HOMA-IR、FAI均有统计学意义(P<0.05)。结论维生素D联合二甲双胍、中药治疗PCOS,有助于改善患者内分泌代谢紊乱情况。
Objective To investigate the effects of vitamin D combined with metformin and traditional Chinese medicine on endocrine and metabolic disorders in patients with PCOS. Methods A total of 270 PCOS patients were selected and divided into three groups randomly. Each group had 90 cases. Metformin was given to group A, metformin plus TCM was given to group B, metformin plus TCM plus vitamin D were given to group C. The treatment group The cycle is 3 months. FSH, LH, E2, T, SHBG, vitamin D levels and OGTT were measured in all patients before and after treatment, and BMI, FAI and HOMA-IR were calculated. Results Compared with BMI, HOMA-IR and FAI, the A, B and C groups showed statistically significant (P <0.05). Conclusions Vitamin D combined with metformin and traditional Chinese medicine in the treatment of PCOS may help to improve the patients’ endocrine and metabolic disorders.