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目的筛查脑性瘫痪(cerebral palsy,CP)儿童产前危险因素。方法采用1∶2病例对照研究,选择2007年12月—2009年5月在黑龙江省小儿脑性瘫痪防治疗育中心就诊的CP儿童202例为病例组,选择同时期非CP且排除中枢神经系统疾病的儿童404名为对照组,通过问卷调查获取相关信息,采用Logistic回归分析筛查危险因素。结果单因素Logistic回归分析共36项因素有统计学意义。多因素Logistic回归分析显示,CP产前危险因素有孕妇大学及以上学历、孕期使用移动或联通移动电话、孕期使用大理石厨台做饭等11项(均P<0.05),另筛查出保护因素为采用剖宫产方式分娩。结论产前危险因素与CP发生关系密切,普及孕产期保健知识、加强孕产妇健康管理是减少CP发生的重要措施。
Objective To screen prenatal risk factors in children with cerebral palsy (CP). Methods A case-control study of 1: 2 was conducted. Totally 202 CP children who were treated in Pediatric Cerebral Palsy Prevention and Healing Center of Heilongjiang Province from December 2007 to May 2009 were selected as case group. The same period non-CP and exclusion of central nervous system 404 children with the disease as the control group, obtained the relevant information through questionnaire survey, and used Logistic regression analysis to screen the risk factors. Results Single factor Logistic regression analysis of a total of 36 factors were statistically significant. Multivariate logistic regression analysis showed that prenatal risk factors of CP were 11 college students with college education or above, mobile or Unicom mobile phone during pregnancy, and cooking with marble kitchen during pregnancy (all P <0.05), and other protective factors For the use of cesarean delivery. Conclusion Prenatal risk factors are closely related to the occurrence of CP, popularizing the knowledge of maternal health and strengthening maternal health management are important measures to reduce the incidence of CP.