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高级醇疏水性好,能量密度高,能与汽油随意混合;用微生物发酵可再生材料生产高级醇燃料替代矿物燃料是发展趋势。文中综述了构建合成高级醇的酿酒酵母和大肠杆菌细胞工厂的研究和相关技术平台。重点介绍了依赖CoA的梭菌途径和α-酮酸介导的非发酵途径的构建,分析了各自的特点,总结了生产高级醇的微生物细胞工厂的构建策略;提出高级醇工业化生产要解决的问题和研究方向。
High alcohol hydrophobic, high energy density, can be freely mixed with gasoline; microbial fermentation of renewable materials to produce higher alcohol fuel alternative fossil fuels is the development trend. This article reviews the research and related technology platforms for the construction of the Saccharomyces cerevisiae and Escherichia coli cell factories that synthesize higher alcohols. The pathways of CoA-dependent Clostridium-dependent and α-keto acid-mediated non-fermentative pathways were mainly introduced. Their respective characteristics were analyzed. The strategies for constructing microbial cell factories for producing higher alcohols were summarized. The industrialization of higher alcohols to be solved Problems and research directions.