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慢性丙型肝炎病毒感染与进行性肝病有关,约1/3患者在20年内发展成肝硬化,甚至相当数量人群发展成肝细胞性肝癌或肝功能衰竭。这些因丙型肝炎所引起的并发症是当前肝脏移植的主要指征。全球至少有1亿人口患慢性丙型肝炎,仅在德国患慢性丙型肝炎的人数达800000人。疾病病程呈隐匿性经过,为疾病统计埋下错误估计的危险。此外,还有慢性丙型肝炎的肝外表现,特别是出现非霍奇金淋巴瘤,均为丙型肝炎的治疗提出迫切要求。
Chronic hepatitis C virus infection is associated with progressive liver disease. Approximately one-third of patients develop cirrhosis within 20 years and even a substantial number develop hepatocellular carcinoma or liver failure. These complications caused by Hepatitis C are the major indications of current liver transplantation. At least 100 million people in the world have chronic hepatitis C, and there are 800,000 people with chronic hepatitis C in Germany alone. The course of the disease is an occult, laying the risk of miscalculation of the disease statistics. In addition, there are extrahepatic manifestations of chronic hepatitis C, in particular, non-Hodgkin’s lymphoma, all of the urgent requirements for the treatment of hepatitis C.