转化生长因子-β1及其基因多态性与慢性阻塞性肺疾病相关性的研究进展

来源 :国际呼吸杂志 | 被引量 : 0次 | 上传用户:duidui1314
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慢性阻塞性肺疾病的发病率和死亡率在逐年升高,目前对其发病机制并未完全清楚,故对其发病机制的研究愈发重要.近年来的研究表明COPD是一种多基因调控的疾病.转化生长因子-β1(transforming growth factor-β1,TGF-β1)是一种多效性细胞因子,近年来倍受关注.研究认为,TGF-β1基因是COPD发生、发展的相关候选基因.现就TGF-β1的来源、分子结构、活化、信号转导、生物学功能、基因多态性及其与COPD相关性的研究进展进行概述.
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