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GABA_A和GABA_B受体的选择性配基进行的药理研究证明,这两种受体亚型存在于外周组织。GABA_B受体是调节肺功能的一种重要的受体亚型。GABA_B受体激动剂可抑制呼吸道的多种反应,选择性GABA_B受体激动剂可用于治疗呼吸系统疾病,如哮喘。
Pharmacological studies with selective ligands for GABA_A and GABA_B receptors demonstrate that these two receptor subtypes are present in peripheral tissues. The GABA_B receptor is an important receptor subtype that regulates lung function. GABA_B receptor agonists suppress multiple respiratory responses and selective GABA_B receptor agonists are used to treat respiratory diseases such as asthma.