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蛋白-蛋白互作(protein-protein interaction,PPI)是发生在有机体里的必要的过程。近年来,越来越多的研究者把PPI作为靶点研发新的药物,尤其是抗人类免疫缺陷病毒(HIV)药物。本文综述了HIV感染进程中发挥重要作用的PPI,以及阻断这些PPI的多肽及小分子的应用。
Protein-protein interaction (PPI) is an essential process that occurs in organisms. In recent years, more and more researchers have been targeting PPIs to develop new drugs, especially anti-human immunodeficiency virus (HIV) drugs. This article reviews PPIs that play an important role in HIV infection and the use of peptides and small molecules that block these PPIs.