Snail、E-cadherin与上皮性肿瘤浸润、转移的关系

来源 :实用肿瘤学杂志 | 被引量 : 0次 | 上传用户:MR65445
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肿瘤经常被看作是正常发育过程的破坏形式,一些在胚胎发育期起重要作用的基因常常在癌组织中被发现,提示它们可能参与一些启动肿瘤发生和促进肿瘤转移的关键步骤,包括局限性侵袭,通过体循环播散,甚至转移。抑制E-cadherin转录的一些调控因子被证明是在胚胎发育期启动上皮细胞间 Tumors are often seen as a disruptive form of normal development. Some genes that play important roles during embryonic development are often found in cancerous tissues, suggesting that they may be involved in a number of key steps in initiating tumorigenesis and promoting tumor metastasis, including limitations Invasion, spread through the systemic circulation, or even transfer. Some regulators of E-cadherin transcription have been shown to activate epithelial cells during embryonic development
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