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目的 :研究鼻息肉组织中肿瘤坏死因子α(tumor necrosis factor,TNF-α)和 CD6 8的表达及其相关性 ,探讨二者与鼻息肉发病机理的关系。方法 :分别以 TNF-α和 CD6 8单克隆抗体对 19例鼻息肉组织和 8例慢性鼻炎鼻粘膜进行免疫组织化学染色。结果 :鼻息肉组织中 TNF-α的表达明显高于对照组 (P <0 .0 5 ) ,在鼻息肉上皮层和固有层有大量 CD6 8阳性细胞 ,且与 TNF-α相关 (r=0 .6 15 )。结论 :本文结果提示鼻息肉中的巨噬细胞作为抗原递呈细胞行使免疫应答 ,上调 TNF-α的合成和分泌。
Objective: To study the expression of tumor necrosis factor (TNF-α) and CD6 8 in nasal polyps and the relationship between the two and the pathogenesis of nasal polyps. Methods: Immunohistochemical staining was performed on 19 cases of nasal polyps and 8 cases of chronic rhinitis nasal mucosa with TNF-α and CD68 monoclonal antibodies respectively. Results: The expression of TNF-α in nasal polyps was significantly higher than that in the control group (P <0.05). There were a large number of CD68 positive cells in the epithelial and lamina propria of nasal polyps, which were correlated with TNF-α (r = 0 .6 15). CONCLUSIONS: Our results suggest that macrophages in nasal polyps function as antigen presenting cells and upregulate TNF-α production and secretion.