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作者曾证实,Crohn’s病(CD)病人血浆弹性蛋白酶,蛋白酶抑制剂复合物(EPIC)升高,但在活动性溃疡性结肠炎(uc)中只是轻度升高。我们设想肠腔内容物EPIC 水平较之血浆可能与疾病活动性有更好的相关性。对象和方法取20例CD 病人、16例UC 病人和10例正常对照者没有尿液混杂的新鲜粪便样品,测重,同时测血白细胞计数和血浆EPIC 和C-反应蛋白(CRP)水平(ELISA法)。采用Mann-Whit-ney 和Spearman 相关实验处理各组数据。结果EPIC 的标准曲线从1到50.0μg/L 呈线性。活动性CD 血浆EPIC 和CRP 水平明显高于活动性UC)但二者粪便EPIC 水平分别为478和1159μg/
The authors have demonstrated elevated plasma elastase and protease inhibitor complex (EPIC) levels in patients with Crohn’s disease (CD) but only mildly elevated levels in active ulcerative colitis (uc). We hypothesized that the level of EPIC in the luminal contents may have a better correlation with plasma activity than disease activity. Subjects and Methods Twenty patients with CD, 16 patients with UC, and 10 normal controls were excluded from the test. Fresh stool samples mixed with no urine were measured, measured for weight, white blood cell count and plasma levels of EPIC and C-reactive protein (CRP) law). Each group of data was processed using the Mann-Whit-ney and Spearman correlation experiments. Results The standard curve of EPIC was linear from 1 to 50.0 μg / L. Active CD plasma levels of EPIC and CRP were significantly higher than those of active UC), but their EPIC levels were 478 and 1159 μg /