手足皮肤反应简称HFSR(hand-foot skin reaction),手足综合征简称HFS(hand-foot syndrome)。引致HFSR的药物主要为多激酶抑制剂索拉非尼(sorafanib)和舒尼替尼(sunitinib);引起HFS的药物主要为化疗药物,如氟尿嘧啶、卡培他滨、多柔比星等。HFSR和HFS的临床表现有相似之处,因此 Hand-foot skin reaction referred to as HFSR (hand-foot skin reaction), hand-foot syndrome referred to as HFS (hand-foot syndrome). The drugs that cause HFSR are mainly multi-kinase inhibitors sorafanib and sunitinib; the drugs that cause HFS are mainly chemotherapeutic drugs such as fluorouracil, capecitabine, doxorubicin and the like. HFSR and HFS clinical manifestations of similarities, therefore