The grey system theory and the artificial neural network technology were applied to predict the sewing technical condition. The representative parameters, such as needle, stitch, were selected. Prediction model was established based on the different fabrics mechanical properties that measured by KES instrument. Grey relevant degree analysis was applied to choose the input parameters of the neural network. The result showed that prediction model has good precision. The average relative error was 4.08% for needle and 4.25% for stitch.