目的:考察枳椇水提取液对四氧嘧啶糖尿病小鼠血糖和肝糖原含量的影响。方法:小鼠按250mg/kg灌胃给予四氧嘧啶,3大后,连续7天灌胃给予枳椇水提取液,禁食16 h后,分别测定血糖和肝糖原含量。结果:枳椇水提取液剂量为5,10或20 g生药/kg·d×7天时,显著降低四氧嘧啶糖尿病小鼠的血糖含量;中、低剂量还显著升高小鼠肝糖原含量。结论:枳椇水提取液有可能成为治疗糖尿病的有效药物。 OBJECTIVE: To investigate the effects of Ginseng extract on blood glucose and hepatic glycogen content in alloxan-induced diabetic mice. METHODS: Mice were given intragastric administration of 250 mg/kg of alloxan, and 3 rats were given gavage for 7 consecutive days. After fasting for 16 h, blood glucose and hepatic glycogen content were measured. RESULTS: When the dosage of Radix Astragali was 5, 10 or 20 g crude drug/kg·d×7 days, the blood glucose level of alloxan-induced diabetic mice was significantly decreased. The middle and low doses also significantly increased the liver glycogen content in mice. . Conclusion: Dianhui extract may be an effective drug for the treatment of diabetes.