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目的:研究低温等离子刀联合匹多莫德对小儿喉乳头状瘤的治疗效果。方法:对黄石市中心医院及武汉市儿童医院2009-2014年诊疗的小儿喉乳头状瘤43例完整随访病历资料进行分析。根据治疗方法分为CO2激光联合匹多莫德组(A组)及低温等离子刀联合匹多莫德组(B组)。记录不同方法治疗后患儿肿瘤复发情况,统计复发率和复发时间,并运用解剖划分法,以此作为不同方法治疗的疗效指标。结果:两组复发率统计学无差异(61.90%vs 59.09%)(P>0.05),但B组复发时间[(8.13±1.17)月]要长于A组[(6.21±1.08月])(P<0.05);两组术前平均解剖亚区为(3.85±1.45)和(3.64±1.57),两组之间无统计学意义(P>0.05),术后3月和6月A组平均(1.82±0.98)和(2.52±1.18)个解剖亚区,B组平均(1.28±0.69)和(1.88±0.79)个解剖亚区,B组均要少于A组,差异有统计学意义(P<0.05)。结论:低温等离子刀联合匹多莫德治疗小儿乳头状瘤,能够有效延长肿物复发时间,使乳头状瘤复发范围较小,值得在临床上推广应用。
Objective: To study the therapeutic effect of low temperature plasma knife combined with pidotimod on pediatric laryngeal papilloma. Methods: Forty-three cases of pediatric laryngeal papilloma from 2009 to 2014 in Huangshi Central Hospital and Wuhan Children’s Hospital were analyzed. According to the treatment, CO2 laser combined with pidotimod group (group A) and low temperature plasma knife combined with pidotimod group (group B). The recurrence rate, recurrence rate and recurrence time of the children with different methods were recorded, and the anatomic classification method was used as the curative index of different methods of treatment. Results: The relapse rate was no significant difference between the two groups (61.90% vs 59.09%) (P> 0.05), but the recurrence time in group B (8.13 ± 1.17 months) was longer than that in group A (6.21 ± 1.08 months) <0.05). The average preoperative anatomic subregions were (3.85 ± 1.45) and (3.64 ± 1.57) in both groups, with no significant difference between the two groups (P> 0.05) 1.82 ± 0.98) and (2.52 ± 1.18) anatomical subregions, the average of (1.28 ± 0.69) and (1.88 ± 0.79) anatomical subsets of group B were less than that of group A, the difference was statistically significant (P <0.05). Conclusion: Low temperature plasma knife combined with pidotimod in the treatment of papilloma in children can effectively prolong the time of tumor recurrence and make the recurrence range of papilloma smaller, which is worth popularizing and applying in clinic.