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目的:研究甲状腺自身抗体在碘-131治疗甲亢后致早发甲减的临床意义。方法:选取2014年7月该院接受碘-131治疗的160例甲亢患者作为研究对象,将所有患者根据治疗前TMAb、TGAb以及TRAb的水平分为4组。观察比较四组患者甲减的发生率。结果:第1组与第3组,第4组比较,第2组与第3组,第4组比较,第4组显著高于前三组,第2组显著高于第3组,所有组别比较,差异有统计学意义(P<0.05)。结论:TMAb、TGAb是碘-131治疗甲亢后后致早发甲减的主要影响因素,TRAb的影响较小。
Objective: To study the clinical significance of thyroid autoantibodies in early hypothyroidism after iodine-131 treatment of hyperthyroidism. METHODS: A total of 160 hyperthyroidism patients treated with iodine-131 in our hospital from July 2014 were selected as study subjects. All patients were divided into 4 groups according to the levels of TMAb, TGAb and TRAb before treatment. The incidence of hypothyroidism in the four groups was observed and compared. Results: Compared with the first three groups, the third group and the fourth group, the second group and the third group and the fourth group, the fourth group was significantly higher than the first three groups, the second group was significantly higher than the third group, all groups Do not compare, the difference was statistically significant (P <0.05). Conclusion: TMAb and TGAb are the main influencing factors of early hypothyroidism after iodine-131 treatment of hyperthyroidism, and the effect of TRAb is small.