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目的观察低剂量米非司酮治疗围绝经期功能失调性子宫出血的临床效果。方法将确诊为围绝经期功能失调性子宫出血的38例患者于晚上睡前空腹给予口服米非司酮10 mg,连服3个月为一疗程,用药前后分别测定血清内分泌水平、肝肾功能及血常规,观察月经情况,同时B超监测子宫内膜厚度。结果米非司酮治疗患者服药期间均闭经。结论小剂量米非司酮治疗围绝经期功能失调性子宫出血疗效肯定,无肝肾功能损害,是一种安全有效的治疗方法。
Objective To observe the clinical efficacy of low-dose mifepristone in the treatment of dysfunctional uterine bleeding in perimenopausal period. Methods Thirty-eight patients diagnosed as peri-menopausal dysfunctional uterine bleeding were given 10 mg mifepristone orally at bedtime before going to bed at night. The patients were treated with three months for one course of treatment. The level of serum endocrine, liver and kidney function And blood, observe the menstrual situation, while B-monitoring of endometrial thickness. Results Mifepristone patients were amenorrhea during medication. Conclusion Small dose of mifepristone treatment of climacteric dysfunctional uterine bleeding with certain efficacy, no liver and kidney dysfunction, is a safe and effective treatment.