目的观察神经生长因子佐治儿童难治性Tourette综合征的疗效。方法将儿童难治性Tourette综合征55例随机分为治疗组30例和对照组25例,两组均予氟哌啶醇及心理治疗,治疗组在原氟哌啶醇治疗基础上加用神经生长因子4μg隔天肌注,2个月为1个疗程。对照组增加氟哌啶醇剂量。结果治疗组痊愈5例,好转23例,无效2例,有效率为93.33%。对照组好转15例,无效10例,有效率为60.00%。两组疗效比较差异有显著性意义(P<0.05)。治疗组不良反应明显少于对照组(P<0.05)。结论神经生长因子佐治儿童难治性Tourette综合征疗效可靠,不良反应轻,对日常生活和学习干扰少。 Objective To observe the curative effect of nerve growth factor in children with Tourette syndrome refractory. Methods Fifty-five children with intractable Tourette’s syndrome were randomly divided into treatment group (n = 30) and control group (n = 25). Both groups were given haloperidol and psychological treatment. The treatment group was treated with haloperidol and nerve growth Factor 4μg intramuscular injection the next day, 2 months for a course of treatment. The control group increased haloperidol dose. Results The treatment group recovered in 5 cases, improved in 23 cases, 2 cases, the effective rate was 93.33%. Control group improved in 15 cases, ineffective in 10 cases, the effective rate was 60.00%. The difference between the two groups was significant (P <0.05). Adverse reactions in the treatment group were significantly less than those in the control group (P <0.05). Conclusion Nerve growth factor adjuvant treatment of children with Tourette syndrome refractory, reliable, light adverse reactions to daily life and less.