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一、抗菌药物的吸收、分布和排泄无论口服(口服不吸收者除外)、肌注、静注或静滴,抗生素的血药浓度一般于给药后0.5～4小时内到达高峰。吸收后迅速分布至各组织、胸、腹腔和体液中,肝、肾、肺组织的药物浓度大多较高,约为血浓度的50～100％,但也常有组织中浓度高出血浓度数倍者。
First, the absorption, distribution and excretion of antibacterial drugs Whether orally (oral non-absorbed except), intramuscular, intravenous or intravenous infusion, the antibiotic blood drug concentration generally within 0.5 to 4 hours after administration peak. Absorbed rapidly distributed to various tissues, thorax, abdomen and body fluids, liver, kidney, lung tissue drug concentration is higher, about 50 to 100% of the blood concentration, but often the tissue concentration higher than the concentration of several times By.