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目的 :研究黄竹定痫胶囊对戊四唑(PTZ)点燃型癫痫大鼠癫痫发作的影响,探讨黄竹定痫胶囊抗癫痫作用机理。方法 :大剂量组灌服黄竹定痫胶囊6 mL,3次/d;小剂量组灌服黄竹定痫胶囊2 mL,3次/d;持续28 d。丙戊酸钠组灌服丙戊酸钠400 mg/kg,3次/d,连续28 d。正常对照组、模型对照组连续28 d灌服生理盐水,3次/d,1mL/次,持续28 d。观察癫痫大鼠体重、惊厥发作级别及持续时间的变化。结果 :PTZ点燃癫痫大鼠体重增加,惊厥发作级别降低,发作持续时间缩短。表明黄竹定痫胶囊具有良好的抗癫痫作用;而中药大剂量组与小剂量组比较有显著性差异,表明黄竹定痫胶囊抗癫痫的作用与剂量成正相关。结论 :黄竹定痫胶囊能显著抑制大鼠戊四唑点燃发作。
Objective: To study the effect of Huangzhu Dingxian Capsule on the epileptic seizures induced by pentylenetetrazole (PTZ) in epileptic rats and explore the anticonvulsant mechanism of Huangzhu Dingxian Capsule. Methods: The high-dose group was given Huangzhiding epilepsy capsule 6 mL, 3 times / d; the low-dose group was given Huangzhiding epilepsy capsule 2 mL 3 times per day for 28 days. Sodium valproate group was infused with sodium valproate 400 mg / kg three times daily for 28 days. Normal control group and model control group were given normal saline for 28 days continuously, 3 times / d, 1ml / time for 28 days. The changes of body weight, seizure severity and duration of epilepsy were observed. Results: The body weight of PTZ-ignited epilepsy rats decreased, the seizure severity decreased and the duration of seizure shortened. Indicating that Huangzhu Dingxian Capsule has a good anti-epileptic effect; and Chinese medicine high-dose group and the low-dose group were significantly different, indicating that the anti-epileptic effect of Huangzhu Dingxie Capsules and dose is positively correlated. Conclusion: Huangzhu Dingxian Capsule can significantly inhibit the onset of pentylenetetrazole in rats.