论文部分内容阅读
目的:研究红花黄色素在大鼠各肠段的吸收动力学特征。方法:采用大鼠在体肠段灌流实验,主要从药物浓度、pH值、吸收部位等3方面对红花黄色素的肠段吸收特性进行研究。结果:在5μg·mL~(-1)～20μg·mL~(-1)浓度范围内药物浓度对吸收速率常数无影响;在pH7.8～pH5.4内药物吸收不受pH值影响;各肠段的吸收速率常数按空肠、十二指肠、回肠、结肠顺序依次下降,分别为0.1116,0.0753,0.0739,0.0185h~(-1)。结论:药物吸收符合一级动力学特征,吸收机制为被动扩散。
Objective: To study the absorption kinetics of safflower yellow pigment in rat intestine. METHODS: Intestinal perfusion was performed in rats. The intestinal absorption characteristics of safflor yellow were studied in terms of drug concentration, pH, and absorption sites. RESULTS: The drug concentration had no effect on the absorption rate constant in the concentration range of 5 μg·mL -1 -20 μg·mL -1; the drug absorption was not affected by pH value in pH 7.8 - pH 5.4; Absorption rate constants in the intestines decreased in the order of jejunum, duodenum, ileum, and colon, and they were 0.1116, 0.0753, 0.0739, and 0.0185h-1, respectively. Conclusion: Drug absorption follows the first-order kinetics, and the absorption mechanism is passive diffusion.