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目的探讨血浆置换治疗重型肝炎的疗效及安全性。方法对72例重型肝炎患者在综合治疗的基础上进行血浆置换(PE),对治疗前后的症状、肝功能、肾功能、电解质、凝血酶原活动度、总胆汁酸及并发症发生情况进行分析。结果PE治疗后患者症状均有不同程度缓解,胆红素、总胆汁酸及转氨酶下降明显,凝血酶原活动度升高显著,总有效率达82.85%,且首次治疗时间不同,治愈率差异有统计学意义(早期82.98%,中期53.33%,晚期12.50%)。血浆置换的并发症少。结论PE治疗重型肝炎安全有效,以早、中期治疗为宜。
Objective To investigate the efficacy and safety of plasma exchange in the treatment of severe hepatitis. Methods Seventy-two patients with severe hepatitis were treated with plasma exchange (PE). The symptoms, liver function, renal function, electrolytes, prothrombin activity, total bile acid and complications before and after treatment were analyzed . Results After treatment with PE, the symptoms of patients were relieved to varying degrees. The levels of bilirubin, total bile acid and aminotransferase decreased significantly. The activity of prothrombin increased significantly. The total effective rate was 82.85%. The first treatment time was different. The difference of cure rate was Statistical significance (early 82.98%, mid-term 53.33%, late 12.50%). Less complications of plasma exchange. Conclusions PE treatment of severe hepatitis is safe and effective, with early and mid-term treatment is appropriate.