Activation of MRGPRB2 receptor in mouse peritoneal mast cells depends on PLC-IP3-ORAI1 pathway

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OBJECTIVE A novel mast cell-specific G-protein-coupled receptor(GPCR),known as mas-related GPCR-B2(MRGPRB2),plays important roles in the immune response.The opening of ion channels mediated by MRGPRB2 activation remains unclear.METHODS AND RE⁃SULTS Calciu
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