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子宫内膜异位症(endometriosis,EMS)是常见的良性妇科疾病,但具有浸润、转移及复发的恶性行为,其发病机制尚不清楚。近年来研究显示,子宫内膜细胞的异位浸润及转移是一个多阶段、多因素参与的复杂过程,其调节涉及多条信号转导通路如Wnt/β-连环素、MAPK、PI3K、NF-κB、Rho/ROCK、JAK/STAT3、TGF-β/Smad。不同的信号转导通路产生了一个复杂的信号网络,最终影响EMS异位内膜黏附、侵袭及血管生成。
Endometriosis (EMS) is a common benign gynecological disease, but the malignant behavior of infiltration, metastasis and recurrence is unclear. In recent years, studies have shown that ectopic infiltration and metastasis of endometrial cells is a multi-stage and multi-factor involved complex process involving many signal transduction pathways such as Wnt / β-catenin, MAPK, PI3K, NF- κB, Rho / ROCK, JAK / STAT3, TGF-β / Smad. Different signal transduction pathways produce a complex network of signals that ultimately affect adhesion, invasion and angiogenesis in the ectopic endometrium of the EMS.