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Mg 是保持人体健康,维持体内电解质平衡,预防疾病不可缺少的微量元素之一。饮食、药物、疾病等均可影响 Mg 的代谢。本文着重阐述药物与 Mg 之间的关系。镁的病理生理Mg 是细胞内含量占第二位的金属元素,参与体内约300种酶反应,具有各种生理活性,是保持线粒体功能、氧化磷酸化、免疫反应和神经肌肉兴奋性不可缺少的物质。Mg 具有 Ca 拮抗作用以及膜稳定和节能(ATP)作用。Na-K ATP 酶是 Mg 依赖性的酶。Mg缺乏时平滑肌收缩增强、血清脂质增加以及通过影响凝血酶而促进血液凝集,引起高血压、动脉硬化和缺血性心脏病等。另外,Mg缺乏时使细胞内 K 外移而改变膜的静电位,使乙酰胆碱的作用增强而发生肌肉痉挛,出现沃斯特克(Chvostek)征和特鲁索(Trous-seau)现象。
Mg is one of the trace elements essential for maintaining human health, maintaining electrolyte balance in the body, and preventing diseases. Diet, drugs, diseases, etc. can affect the metabolism of Mg. This article focuses on the relationship between drugs and Mg. Pathophysiology of magnesium Mg is the second largest intracellular content of metal elements involved in the body about 300 kinds of enzyme reactions, with a variety of physiological activity, is to maintain mitochondrial function, oxidative phosphorylation, immune response and neuromuscular excitability is indispensable substance. Mg has Ca antagonism and membrane stability and energy-saving (ATP) effects. Na-K ATPase is a Mg-dependent enzyme. Smooth muscle contraction increases with Mg deficiency, increased serum lipids, and promotes blood coagulation by affecting thrombin, causing hypertension, arteriosclerosis and ischemic heart disease. In addition, when Mg is deficient, the intracellular K is relocated to change the electrostatic potential of the membrane, thereby enhancing the action of acetylcholine and causing muscle spasms. Chvostek sign and Trous-seau phenomenon appear.