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目的观察拉萨地区藏族T2DM患者在口服降糖药物基础上加用地特胰岛素(Det)或甘精胰岛素(Gla)治疗对血糖和体重的影响。方法 70例拉萨地区藏族T2DM患者,在1种或2种口服降糖药的基础上加用Det或Gla。结果治疗3个月后,两组血糖均得到有效控制,加用Gla的T2DM患者体重增加1.3kg,加用Det增加0.2kg。结论拉萨地区藏族T2DM患者在口服降糖药物同时加用基础胰岛素治疗降糖效果较好,低血糖发生率低,而且能减少体重的增加。
Objective To investigate the effect of oral glucose-lowering and body weight gain on the treatment of T2DM patients with LAD in Tibet based on oral antidiabetic drugs plus Det or Glargine (Gla). Methods Seventy patients with T2DM in Tibet were enrolled in this study. Det or Gla was added to one or two oral hypoglycemic agents. Results Three months after treatment, blood glucose was effectively controlled in both groups. The body weight of T2DM patients with Gla increased by 1.3 kg and Det with 0.2 kg. Conclusion The Tibetan patients with T2DM in Lhasa have better hypoglycemic effect with oral hypoglycemic drugs plus basal insulin therapy, lower incidence of hypoglycemia, and lower body weight gain.