炔丙醇和芳基异氰在银催化条件下能够发生交叉偶联反应,高产率地生成N-芳基-2,3-联烯酰胺.该反应具有条件温和、原子经济性和底物范围宽泛等优点,多种芳基异腈和炔丙醇均能发生交叉偶联反应,并生成相应的N-芳基-2,3-联烯酰胺.该方法解决了前期工作中异腈种类受限的问题,为合成N-芳基联烯酰胺提供了简便新途径. Propargyl alcohol and aryl isocyanide cross-coupling reaction can be carried out under silver catalysis, yielding N-aryl-2,3-enenamide with high yield, with mild conditions, wide range of atomic economy and substrate Etc., a variety of aryl isonitrile and propargyl alcohol cross-coupling reaction can occur, and generate the corresponding N-aryl -2,3-enamide amide. This method solves the preliminary work Isonitrile species limited The problem, for the synthesis of N-aryl-enamide amide provides a simple new way.