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目的追踪过期四环素中毒患者的预后,探讨过期四环素对人体的长期影响。方法对2001年本地区发生的60例过期四环素中毒患者进行了电话随访、临床复查、司法鉴定。结果1年后26例(43,3%)患者仍有临床表现,其中11例为神经衰弱表现,6例为继发性脑损害表现(致残)、4例为上腹部症状,5例为原有伴随病加重。2年后随访5例有神经衰弱表现,6例继发性脑损害无变化。结论过期四环素临床预后不良,继发性脑损害、神经-肌肉损害是影响患者预后的主要因素。
Objective To track the prognosis of patients with tetracycline overdose and to explore the long-term effects of tetracycline overdose on the human body. Methods A total of 60 cases of tetracycline poisoning in the region were investigated by phone, clinical review and forensic examination in 2001. Results One year later, 26 (43%) patients had clinical manifestations, of which 11 were neurasthenic, 6 were secondary to brain damage (disability), 4 were upper abdominal symptoms and 5 were The original concomitant disease increased. Five cases were followed up for 2 years with neurasthenia, while 6 cases showed no change in secondary brain damage. Conclusions The out-of-date tetracycline clinical prognosis is poor. Secondary brain damage and neuromuscular damage are the main factors affecting the prognosis of patients.