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目的探讨局部应用人纤维蛋白胶 (FS)对实验性肝损伤的止血和护创作用。方法采用大鼠肝表面裂伤 (Ⅰ型 )和部分肝切除断面伤 (Ⅱ型 )模型 ,以自然止血法为阴性对照 ,缝合止血法和凝血酶止血法为阳性对照 ,比较各组间创面止血时间和术后d 1、4、7、14及 5 0光镜下创面愈合情况。结果与自然止血组相比 ,FS组对Ⅰ型肝损伤模型止血时间平均缩短 86 .0 % (P <0 .0 1) ,对Ⅱ型肝损伤模型缩短 79.0 % (P <0 .0 1) ;与凝血酶止血法相比 ,FS组止血时间分别缩短 45 .0 %和 84.0 % (P <0 .0 1和P <0 .0 5 )。肉眼和镜下观察 ,FS组创面愈合较快 ,局部组织损伤较轻 ,术后 5 0d腹腔粘连基本消失。结论FS对大鼠肝损伤有明显止血作用 ,并能促进创伤的愈合。
Objective To investigate the effect of topical application of human fibrin glue (FS) on hemostasis and protective effect of experimental liver injury. Methods The model of liver surface laceration (type Ⅰ) and partial hepatectomy (type Ⅱ) were used in this study. The natural hemostatic method was used as the negative control, the suture hemostatic method and the thrombin hemostasis method were used as positive control. The wound hemostasis Time and postoperative d 1,4,7,14 and 5 0 under the light microscope wound healing. Results Compared with the natural hemostatic group, the hemostatic time of FS group was reduced by 86.0% (P <0.01) on average, and 79.0% (P <0. 01) Compared with thrombin hemostasis, the bleeding time of FS group was shortened by 45.0% and 84.0% (P <0.01 and P <0.05), respectively. Macroscopic and microscopic observation, FS group wound healing faster, less local tissue damage, 50d postoperative abdominal adhesions disappeared. Conclusion FS has obvious hemostatic effect on liver injury in rats and can promote wound healing.