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目的探讨复方丹参注射液和小剂量肝素对新生儿硬肿症(中、重度)的治疗效果。方法将61例新生儿硬肿症(中、重度)患儿随机分为治疗组32例,对照组29例,两组均采用暖箱复温、控制感染、补充足够能量及液体、纠正器官功能紊乱等。治疗组加用复方丹参注射液1~2ml/(kg·d)静脉滴注,1次/d。同时给予小剂量肝素10U/(kg.次),1次/12h,皮下注射,疗程3~5d。结果总有效率治疗组为87.5%,对照组为62.1%,治疗组在体温恢复正常时间、硬肿消退时间、吮奶量及哭声增大时间、住院时间等均短于对照组,差异有统计学意义(P<0.05)。结论复方丹参注射液和小剂量肝素对中、重度新生儿硬肿症疗效显著可靠,方便易行,值得在基层医院推广。
Objective To investigate the therapeutic effect of compound Danshen injection and low-dose heparin on neonatal sclerema (moderate and severe). Methods Thirty-six neonates with scleredema (moderate or severe) were randomly divided into treatment group (n = 32) and control group (n = 29). Both groups were treated with warm box rewarming to control infection and supplement enough energy and fluid to correct organ function Disorders and so on. The treatment group plus compound Danshen injection 1 ~ 2ml / (kg · d) intravenous infusion, 1 / d. At the same time given low-dose heparin 10U / (kg. Times), 1 / 12h, subcutaneous injection, treatment of 3 ~ 5d. Results The total effective rate was 87.5% in the treatment group and 62.1% in the control group. The treatment group had shorter body temperature recovery time, sclerema regression time, suckling milk volume, longer crying time and shorter hospital stay, Statistical significance (P <0.05). Conclusion The compound Danshen injection and low-dose heparin have obvious and reliable curative effect on moderate and severe neonatal scleroses, which is convenient and easy to be implemented and is worth popularizing in primary hospitals.