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在联合王国(UK)二乙酰吗啡和吗啡常被用于术后镇痛,但不论病人或动物实验(犬)在用该两药后常产生明显的组胺释放.作者选择了36例腹部手术病人,按随机双盲法进行观察.全部病人术前均用替马西泮(羟基安定)和芬太尼.术后先取基础血样.当病人主诉疼痛时随机双盲静注吗啡0.16mg/kg或二乙酰吗啡0.08mg/kg.注药后1、2.5、5、10、15、20分钟后再取血样,用单一同位素放射酶技术检测组胺含量.血浆组胺浓度大于1mg/kg或比原来值高400%时,定为组胺释放.用线性视觉摸拟计分法评估疼痛程度.
Diacetylmorphine and morphine are commonly used for postoperative analgesia in the United Kingdom (UK), but significant histamine release is often observed in both patients and animals (dogs) after administration of the two drugs. The authors selected 36 cases of abdominal surgery Patients were randomized to double-blind observation. All patients were treated with temazepam and fentanyl before surgery, and baseline blood samples were taken before surgery. Patients were randomized to receive either morphine 0.16 mg / kg morphine Acetylmorphine 0.08mg / kg .After 1, 2.5, 5, 10, 15 and 20 minutes after injection, blood samples were taken and histamine content was detected by single isotope radioimmunoassay.Histamine concentration in plasma was higher than 1mg / kg or higher than the original value Histamine release at 400% hyperexcitability was assessed by linear visual analogue scoring.