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目的:对妇炎清泡腾片的处方及制备工艺进行研究。方法:采用正交实验设计,以崩解时间、pH值以及发泡量为指标综合评分筛选处方,对妇炎清的处方进行筛选。结果:最佳处方工艺为A1B1C2,即淀粉与浸膏的比例为2:1、枸橼酸与浸膏的比例为1.5:1g、碳酸氢钠与浸膏的比例为1.25:1。结论:经过优化后的处方制备的妇炎清泡腾片各项指标符合药典规定,工艺重现性好,适于规模化生产。
Objective: To study the preparation and prescription of Fu Yan Qing effervescent tablets. Methods: Orthogonal experimental design was used to screen prescriptions based on the composite score of disintegration time, pH value and foaming volume, and the prescription of Fuyanqing was screened. Results: The optimal prescription was A1B1C2, that is, the ratio of starch to extract was 2: 1, the ratio of citric acid to extract was 1.5: 1g, and the ratio of sodium bicarbonate to extract was 1.25: 1. Conclusion: The prescription of Fu Yan Qing effervescent tablets prepared by the optimized prescription conforms to the Pharmacopoeia regulation, the technology has good reproducibility and is suitable for large-scale production.