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目的利用高频超声观测阿托伐他汀对糖尿病患者血管内皮功能的影响。方法将90例2型糖尿病年龄小于45岁无动脉硬化、无高血压、胆固醇的水平正常的患者,按2:1的比例随机分成两组,Ⅰ组为治疗组(60例),给予阿托伐他汀;Ⅱ组为对照组(30例),给予安慰剂。应用高频超声检测糖尿病患者用药前后的肱动脉在测值为静息状态下反应性充血后的内径变化。结果治疗组在治疗一年后肱动脉反应性充血前后的内径变化率明显增高,而对照组变化不明显。结论无动脉硬化、无高血压的既往史及血脂正常的糖尿病患者,给予阿托伐他汀治疗亦能显著改善血管内皮舒张功能。
Objective To observe the effect of atorvastatin on vascular endothelial function in diabetic patients by high frequency ultrasound. Methods 90 patients with type 2 diabetes younger than 45 years without arteriosclerosis, no hypertension and normal cholesterol levels were randomly divided into two groups according to the ratio of 2: 1, group Ⅰ was treated group (60 cases) In the second group, the control group (n = 30) received placebo. Application of high-frequency ultrasound detection of diabetes patients before and after treatment of brachial artery measured at rest in response to changes in the diameter after reactive hyperemia. Results In the treatment group, the change rate of internal diameter before and after brachial artery reactivity hyperemia was significantly increased one year after treatment, while the change in the control group was not obvious. Conclusions Atorvastatin treatment can also significantly improve vascular endothelial relaxation in patients with no previous history of arteriosclerosis and no hypertension and in patients with normal blood lipids.