目的:对甲硫咪唑致甲亢患者粒细胞缺乏合并肝损害的发病情况与临床表现进行探讨与分析,并总结治疗措施。方法:本研究共纳入研究对象15例,均为2011年10月到2013年10月我院收治的甲亢粒细胞缺乏合并肝损害患者,所有患者均为口服甲硫咪唑所致。总结分析患者临床症状和治疗情况。结果:患者多在服药之后的2周到3个月期间出现症状,头晕、发热、身体乏力、咽喉疼痛以及黄疸等是主要表现,15例患者在服用升白细胞、实施保肝、退黄和抗感染,并在停用甲硫咪唑之后,有14例抢救成功,占93.3%,1例抢救无效死亡,占6.67%,死亡原因为粒细胞没有恢复,严重感染、酸中毒。结论:患者在首次服用甲硫咪唑之后要对其外周血白细胞的计数和肝功能情况进行密切观察,这样可以防止出现粒细胞缺乏症,并能够有效避免严重肝损害的发生,临床上要高度重视甲亢患者粒细胞缺乏合并肝损害的发生。 Objective: To investigate and analyze the incidence and clinical manifestation of agranulocytosis with hyperthyroidism induced by methimazole in patients with hyperthyroidism, and to summarize the therapeutic measures. Methods: A total of 15 subjects were enrolled in this study. All of them were patients with hyperthyroid granulocytopenia and liver damage who were admitted to our hospital from October 2011 to October 2013. All of them were caused by oral methimazole. Summary analysis of clinical symptoms and treatment of patients. Results: Most of the patients showed symptoms, dizziness, fever, weakness, sore throat and jaundice during the period of 2 weeks to 3 months after taking the medication. Fifteen patients were taking leukocytes and liver protection, yellowing and anti-infection were performed After the withdrawal of methimazole, 14 patients were successfully rescued, accounting for 93.3%. One patient died of ineffective rescue, accounting for 6.67%. The cause of death was no recovery of granulocytes, severe infection and acidosis. Conclusions: Patients should observe the count of peripheral blood leukocytes and liver function closely after the first dose of methimazole, so as to prevent the occurrence of agranulocytosis and avoid the occurrence of severe liver damage, so it should be highly valued clinically Hyperthyroidism patients with agranulocytosis with liver damage.