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目的分析泉州地区手足口病病原检测结果,了解其病原学特征,为防控提供依据。方法通过手足口病监测网络平台,收集2014—2015年泉州各监测哨点医院送检的1 225份疑似患者咽拭子标本,用实时荧光RT-PCR法先进行肠道病毒通用型(EV)核酸检测,对阳性标本再进行肠道病毒71型(EV71)和柯萨奇肠道病毒A16型(CoxA16)分型,分析检测结果。结果 1 225份标本中,手足口病EV核酸阳性标本936份,阳性率76.4%;2015年阳性率(83.7%)高于2014年(68.3%);其中EV71型占32.7%,CoxA16型占17.4%,其他肠道病毒型占49.9%。发病高峰在3~6月。肠道病毒感染以1~3岁儿童为主,男性高于女性。结论 2014—2015年泉州市手足口病存在季节、人群及地区分布差异,主要病原为其他肠道病毒和EV71,应引起重视。
Objective To analyze the pathogen test results of hand-foot-mouth disease in Quanzhou, understand its etiological characteristics and provide basis for prevention and control. Methods A total of 1 225 suspected throat swabs were collected from all sentinel hospitals in Quanzhou during 2014-2015. The real-time fluorescent RT-PCR method was used to detect the enterovirus (EV) Nucleic acid detection, the positive specimens and then enterovirus 71 (EV71) and Coxsackie A16 type (CoxA16) typing, analysis of test results. Results Among the 1 225 specimens, 936 were positive for EV nucleic acid in hand, foot and mouth disease, the positive rate was 76.4%. The positive rate in 2015 was 83.7%, which was higher than that in 2014 (68.3%). Among them, EV71 accounted for 32.7% and CoxA16 accounted for 17.4 %, Other intestinal virus accounted for 49.9%. The peak incidence in 3 to 6 months. Intestinal virus infection in children aged 1 to 3 dominated, men than women. Conclusion There are differences in seasonal, population and regional distribution of HFMD in Quanzhou between 2014 and 2015. The main pathogens are other enterovirus and EV71, which should be paid more attention to.