目的:观察多潘立酮混悬液预防静脉滴注阿奇霉素时胃肠道反应的临床效果。方法:128例呼吸道感染并在我院静脉滴注阿奇霉素治疗的患儿,随机分为治疗组和对照组各64例。治疗组于静脉滴注阿奇霉素30 min前给予多潘立酮混悬液0.3 mL/kg口服,对照组不给予任何干预,观察两组在阿奇霉素静脉滴注时胃肠道反应(包括腹痛、腹泻、恶心、呕吐)的发生情况。结果:治疗组阿奇霉素静脉滴注后胃肠道反应发生率低于对照组,两组比较差异有统计学意义(χ2=7.38,P<0.05)。结论:口服多潘立酮混悬液可明显减轻阿奇霉素静脉滴注时出现的胃肠道反应,并且能避免严重不良反应的发生。 OBJECTIVE: To observe the clinical effect of domperidone suspension on preventing gastrointestinal reaction when intravenous infusion of azithromycin. Methods: A total of 128 children with respiratory tract infection who were treated with azithromycin in our hospital were randomly divided into treatment group (64 cases) and control group (64 cases). The treatment group was treated with domperidone 0.3 ml / kg orally 30 minutes before intravenous drip. The control group was given no intervention. The two groups were treated with azithromycin intravenous infusion (including abdominal pain, diarrhea, nausea and vomiting) ) Of the occurrence. Results: The incidence of gastrointestinal reactions after azithromycin intravenous drip in the treatment group was lower than that in the control group. There was significant difference between the two groups (χ2 = 7.38, P <0.05). Conclusion: Oral domperidone suspension can obviously relieve the gastrointestinal reaction induced by intravenous infusion of azithromycin, and can avoid serious adverse reactions.