主要表现皮肤角化丘疹糖尿病肝肾病变本征是一种罕见的遗传性毛囊性病变。最早于1916年首先由Kyrle报道。1例22岁女性白人,出现无症状的泛发性丘疹损害,命名为真皮穿通性毛囊及毛囊旁过度角化病。到1967年止文献收集仅45例,1968年Carter等报道5例,并复习文献对本征的临床和病理 The main manifestations of skin keratosis Diabetic liver and kidney disease is a rare intrinsic genetic hair follicular lesions. As early as 1916, first reported by Kyrle. A 22-year-old female white with asymptomatic papular lesions called dermal penetrating hair follicles and follicular hyperkeratosis. By 1967, only 45 cases were collected in the literature, 5 cases were reported by Carter et al in 1968, and reviewed the literature on the intrinsic clinical and pathological