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目的探讨正常T细胞表达和分泌的活性调节蛋白(RANTES)基因启动子区-28C/G多态性与T2DM及其慢性并发症相关危险因素的相关性。方法运用PCR-RFLP技术对178例T2DM患者(T2DM组)和67例正常对照者(NC组)的RANTES基因-28C/G多态性进行检测。结果 NC组和T2DM组间基因型和等位基因频率差异无统计学意义(P>0.05);RANTES基因-28G等位基因携带者血浆HDL-C浓度较非G等位基因携带者低且差异有统计学意义(P<0.05);Logistic回归分析:RAN-TES基因启动子区-28C/G多态性与HDL-C水平无关(P=0.228,OR=1.777),BMI与HDL-C异常呈正相关(P=0.000,OR=2.562)。结论 RANTES基因启动子区-28C/G多态性可能不是昆明地区汉族T2DM发生的危险因素,超重和肥胖可能是T2DM患者HDL-C异常的危险因素。
Objective To investigate the relationship between the -28C / G polymorphism of RANTES gene and the risk factors associated with chronic complications in normal T cells. Methods The RANTES gene -28C / G polymorphisms in 178 patients with T2DM (T2DM group) and 67 normal controls (NC group) were detected by PCR-RFLP. Results There was no significant difference in the genotype and allele frequency between NC group and T2DM group (P> 0.05). The plasma levels of HDL-C in RANTES gene -28G allele were lower than those in non-G allele (P <0.05). Logistic regression analysis showed that the -28C / G polymorphism in RAN-TES promoter region was not associated with HDL-C level (P = 0.228, OR = 1.777) (P = 0.000, OR = 2.562). Conclusion The -28C / G polymorphism of RANTES gene promoter region may not be a risk factor for T2DM in Kunming Han population. Overweight and obesity may be risk factors for HDL-C abnormalities in T2DM patients.