目的建立双核素阴茎海绵体动态显像的定量分析方法，用于评价血管性阳萎。方法用９９ｍＴｃＲＢＣ作阴茎海绵体动脉系统显像，１３１Ｉ邻碘马尿酸（ＯＩＨ）作阴茎海绵体静脉系统显像，并在盐酸罂粟碱负荷下连续测阴茎海绵体内放射性变化。观察１２例正常男子和４２例阳萎病人阴茎海绵体血液动力学变化。结果１２例正常男子９９ｍＴｃ阴茎动脉系统显像指数（ＴＰＩＡ）为２０７±０８４（正常值＞０６０）；１３１Ｉ阴茎静脉系统显像指数（ＩＰＩＶ）为－０３４±０１２（正常值＞－０４８）。根据ＴＰＩＡ和ＩＰＩＶ的结果，４２例阳萎病人被分为３组：１３例ＴＰＩＡ、ＩＰＩＶ正常者为非血管性阳萎组，其ＴＰＩＡ为１９０±０６９，ＩＰＩＶ为－０３６±００８；２１例ＴＰＩＡ正常、ＩＰＩＶ异常者为静脉性阳萎组，ＴＰＩＡ为１９８±０１０，ＩＰＩＶ为－０６７±０１２；８例ＴＰＩＡ异常、ＩＰＩＶ正常或异常者，其ＴＰＩＡ为０３４±０２１，ＩＰＩＶ为－０５５±０１１。结论双核素阴茎海绵体动态显像对评价血管性阳萎，特别是鉴别静脉和动脉系统方面的病理状况是一种安全、无创、客观和有价值的方法 Objective To establish a quantitative method for the dynamic imaging of binuclear phallic cavernosum for the evaluation of vascular impotence. Methods The 99mTcRBC was used for the development of the penile cavernous system. 131IOiodo-hippuric acid (OIH) was used as the penile cavernous venous system imaging. The radioactive changes in the penis were measured continuously under the papaverine hydrochloride load. The hemodynamic changes of penis in 12 normal subjects and 42 impotence patients were observed. Results The imaging index (TPIA) of 99mTc penile arteries was 12.07 ± 0.84 (normal> 060) in 12 normal men. The IPI of 131I penis system was -034 ± 0 12 (normal> -0.48). According to the results of TPIA and IPIV, 42 cases of impotence patients were divided into three groups: 13 cases of TPIA, normal IPIV non-vascular impotence group, the TPIA was 1  90 ± 0  69, IPIV was -0  36 ± 008; 21 cases of TPIA normal, IPIV abnormalities were venous impotence group, TPIA was 1  98 ± 0  10, IPIV was -067 ± 0  12; 8 cases of TPIA abnormalities, IPIV normal or abnormal The TPIA was 034 ± 021, IPIV was -055 ± 011. Conclusions Dual nuclide dynamic imaging of corpus cavernosum is a safe, noninvasive, objective, and valuable method for evaluating vascular impotence, especially in identifying pathological conditions in the venous and arterial systems