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喉癌是头颈部常见的恶性肿瘤,85%～90%为鳞状细胞癌。据统计2011年美国有12 740例新发病例,死亡3 560例。喉癌的发生和发展是多因素、多步骤、多基因共同参与的复杂过程,并受多种信号通路的调节。研究表明蛋白质酪氨酸磷酸化在细胞信号转导过程中起重要作用,不仅参与正常细胞的生长、增殖与分化,而且与肿瘤的发生与
Laryngeal cancer is a common head and neck cancer, 85% to 90% of squamous cell carcinoma. According to statistics, there were 12,740 new cases in the United States in 2011, with 3,560 deaths. The occurrence and development of laryngeal cancer is a multifactorial, multi-step, multi-gene involved in the complex process, and is regulated by a variety of signaling pathways. Studies have shown that protein tyrosine phosphorylation in cell signaling plays an important role, not only involved in normal cell growth, proliferation and differentiation, but also with the tumor occurrence and