Design, synthesis and biological estimation of 1-(benzoxazole-2-y1)piperazine and 4-(benzoxazole-2-y

来源 :中国化学快报（英文版） | 被引量 : 0次 | 上传用户：blzzb001

【摘要】

：

Two series of 1-(benzoxazole-2-yl)piperazine(8a-i)and 4-(benzoxazole-2-yl)piperidine compounds(10a-i)were designed,synthesized and evaluated for their α1-AR an

【作者】

：

Jia Bin Li Lin Xia Bin Wu Tao

【机构】

：

Department of Inorganic Chemistry,Department of Medicinal Chemistry,School of Pharmacy,National Drug

【出处】

：

中国化学快报（英文版）

【发表日期】

：

2004年期

【关键词】

：

BPH α1-AR antagonists Benzoxazole Piperidine Piperazine

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Two series of 1-(benzoxazole-2-yl)piperazine(8a-i)and 4-(benzoxazole-2-yl)piperidine compounds(10a-i)were designed,synthesized and evaluated for their α1-AR antagonistic activities.Biological assay in vitro indicated that 10h showed slightly stronger α1-AR antagonistic activity to that of our lead compound 1.

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Design, synthesis and biological estimation of 1-(benzoxazole-2-y1)piperazine and 4-(benzoxazole-2-y

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