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目的探讨广东省家栖鼠对抗凝血灭鼠剂的抗药性变化。方法按全国鼠类抗药性监测协作组统一方法,进行无选择性摄毒试验。结果经对广东省5市所捕捉的769只褐家鼠、303只黄胸鼠进行抗药性监测,其抗性率分别为1.69%和12.21%,总平均摄药剂量分别为10.36和131.96mg/kg,按家栖鼠抗药性检验标准,黄胸鼠和褐家鼠均对第一代抗凝血剂杀鼠灵产生抗药性个体。结论以黄胸鼠为优势种的场所,要考虑使用第二代抗凝血灭鼠剂;而以褐家鼠为主的场所,则可继续使用第一代抗凝血灭鼠剂,同时应加强对灭鼠药物的敏感性监测,科学、合理用药。
Objective To investigate the changes of drug resistance of anticoagulant rodenticides in domestic animals in Guangdong Province. Methods According to the unified method of the National Collaborating Group on Resistance Investigation of Rodents, a non-selective toxicity test was conducted. Results 769 Rattus norvegicus and 303 Rattus flavipectus captured in 5 cities of Guangdong Province were tested for drug resistance. The resistance rates were 1.69% and 12.21%, respectively. The total average dose was 10.36 and 131.96 mg / kg. According to the standard test of drug resistance of rodents, both Rattus flavipectus and Rattus norvegicus developed drug-resistant individuals to the first-generation anti-coagulant warfarin. Conclusion Rattus flavipectus is the dominant species in the area, we should consider the use of second-generation anticoagulant rodenticides; and Rattus norvegicus-based sites, you can continue to use the first generation of anticoagulant rodenticides, should Strengthen the sensitivity of rodent control drug monitoring, scientific and rational drug use.