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Background:Acupuncture combined with Chinese herbal medicine was performed on 24 patients with post-schizophrenia comorbid depressive disorder and insomnia admitted to the Psychiatry Department,Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine from 2016 to 2020,and provided satisfactory results.Considering post-schizophrenia comorbid depressive disorder and insomnia is not a common clinical disorder in hospital of traditional Chinese medicine,the treatment and follow-up cycle is long,and the dropout rate is high,a retrospective case series based on Joanna Briggs Institute (JBI) reporting checklist were conducted instead of a randomized controlled trial.Objective:To retrospectively summary the short-,mid-and long-term effects of acupuncture combined with Chinese herbal medicine for post-schizophrenia comorbid depressive disorder and insomnia,and analyze the principles of the prescriptions.Methods:A retrospective analysis based on case series JBI reporting checklist were performed to inves-tigate effects of 24 patients with post-schizophrenia comorbid depressive disorder and insomnia under-going 12-week combined acupuncture and Chinese herbal medicine treatment (patients did not receive full dosage treatments,or received western medicine or other physical and psychological therapies dur-ing the treatment period were excluded).The psychotic symptoms,depression,insomnia,and self-care ability for daily living were measured by the Positive and Negative Syndrome Scale (PANSS),Calgary De-pression Scale for Schizophrenia (CDSS),Pittsburgh Sleep Quality Index (PSQI),and Activity of Daily Liv-ing Questionnaire (ADL-Q),respectively.Follow-ups were conducted at 8 and 16 weeks after treatment.Meanwhile,Acupuncture Beliefs Scale (ABS) was assessed at pre-and post-treatment as well as 16-week follow-up to investigate patients\' beliefs and expectations for acupuncture treatment.Results:(1) compared with pre-treatment,the PANSS global scores did not decrease significantly at post-treatment and follow-up periods (P＞ 0.05).(2) compared with pre-treatment,the global scores of CDSS and PSQI decreased significantly at post-treatment and follow-up periods (both P＜ 0.05).The PSQI global scores at the 16-week follow-up were even significantly lower than at port-treatment (P＜ 0.05).(3) after treatment,the ADL-Q global scores decreased significantly (P＜ 0.05),and continued to decrease during the follow-ups (P＜ 0.05).(4) effective treatment improved patients\' beliefs and expectations of acupunc-ture therapy.Conclusions:Acupuncture combined with Chinese herbal medicine can significantly improve the insomnia and depressed mood following schizophrenia,with satisfactory short-,medium-and long-term effects;effective treatment experience can increase patients\' beliefs and expectations for acupuncture therapy.