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目的:探讨乙肝患者血清标志物与肝纤维化血清学指标的相关性。方法:收集我院收治的136例乙型病毒肝炎患者,根据轻中重程度分为轻度组、中度组以及重度组,每组42例。观察并比较所有患者乙肝血清标志物、HBV-DNA水平、透明质酸(HA),血清Ⅲ型前胶原肽(PCⅢ),Ⅳ型胶原(CIV)水平以及层粘连蛋白(LN)水平。结果:三组患者的HBV-DNA水平依次升高,与轻度组相比,中度组、重度组患者HBV-DNA水平较高,与中度组患者相比,重度组患者HBV-DNA水平较高,差异具有统计学意义(P<0.05)。与轻度组相比,中度组、重度组患者HA、PCⅢ、CIV、LN水平较高,与中度组患者相比,重度组患者HA、PCⅢ水平较高,差异具有统计学意义(P<0.05);HBV-DNA水平与HA、PCⅢ、CIV、LN水平均呈显著正相关。结论:乙肝患者的血清学检测指标与血清肝纤维化测定有助于对乙肝的纤维化过程的进展情况进行评估。
Objective: To investigate the correlation between serum markers of hepatitis B patients and serum markers of liver fibrosis. Methods: A total of 136 cases of hepatitis B virus were collected from our hospital and divided into mild group, moderate group and severe group according to their light, medium and severe degree, with 42 cases in each group. All patients were observed for hepatitis B virus markers, HBV-DNA levels, hyaluronic acid (HA), PCⅢ, CIV and LN levels. Results: The level of HBV-DNA in three groups increased in sequence, and the level of HBV-DNA in moderate group and severe group was higher than that in mild group. Compared with moderate group, HBV-DNA level in severe group Higher, the difference was statistically significant (P <0.05). Compared with the mild group, the levels of HA, PCⅢ, CIV and LN in the moderate and severe groups were higher than those in the moderate group, and the levels of HA and PCⅢ in the severe group were higher (P <0.05). HBV-DNA levels were positively correlated with HA, PCⅢ, CIV and LN levels. Conclusion: Serological markers and serum fibrosis in patients with hepatitis B are helpful to evaluate the progress of fibrosis in hepatitis B patients.